Red-Al ® sodium bis(2-methoxyethoxy)aluminum hydride ≥70% wt in Toluene. lithium

Description

Red-Al ® sodium bis(2-methoxyethoxy)aluminum hydride ACS Soln. 70% wt In Toluene. (25g) in amber bottle with Teflon coated cap. Cas# 22722-98-1
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Red-Al is an excellent and best alternative to Lithium Aluminum Hydride (LiAlH4), it does it’s job just as good just much safer. Red-Al is nonpyrophoric, does not require Tetrahydrofuran, Diethyl Ether or any ether for that matter, simple hydrocarbons can be used instead and it already comes in a toluene solution so it’s ready to go but my preference would be to dissolve the compound being reduced in toluene to facilitate a smoother reduction. Also no need for inert gas atmosphere as it’s the case with LiAlH4, the reductions are quick, safer and less stressful! Although not necessary like with LiAlH4, I would still advise to take precaution and use inert gas as it does release flammable gasses or make sure there are no open flames and you have proper ventilation. Safety first right!!
THIS REDUCING AGENT IS THE FUTURE!!!!
Density: 1.036 g/mL at 25 °C
Vapor pressure: 21 mmHg ( 20 °C)
Flash Point(F): 39.2 °F - closed cup
Flash Point(C): 4 °C - closed cup
•Hazard Classifications:
Aquatic Chronic 3 - Asp. Tox. 1 - Eye Dam. 1 - Flam. Liq. 2 - Repr. 2 - Skin Corr. 1B - STOT RE 2 - STOT SE 3 - Water-react. 1
•Target Organs:
Central nervous system
•Storage Class Code:
4.3 - Hazardous materials, which set free flammable gases upon contact with water
Properties:
The pure substance of this product is white solid. The product is in toluene solution. Its decomposition temperature is 205℃. Under dry environment, it can be stored for a long time and does not react with oxygen. As long as it’s not exposed to moisture you will not get any hydrogen buildup in the bottle like you would with LiAlH4 as it tends to release hydrogen gas upon standing while in storage loosing its potency.
🟢General description🟢
Red-Al® sodium bis(2-methoxyethoxy)aluminum hydride [NaAlH2(OCH2CH2OCH3)2] is used as a versatile reducing agent in organic synthesis. It is used to reduce:
Aldehydes, ketones, esters, and anhydrides to primary alcohols.
Ketoximes and aldoximes to primary amines.
Can reduce amide, nitrile, imine and most nitrogen containing organic compounds into the corresponding amines.
Cyclic compounds such as lactones and epoxides to diols.
It is also used as a catalyst in the ring-opening polymerization reactions.
Application:
Red-Al® sodium bis(2-methoxyethoxy)aluminum hydride can be used as:
•A tosyl deprotecting agent.
•A catalyst for crosslinking of polyvinylsilanes (PVS) by Si-Si dehydrocoupling reaction in the presence of group 4 metallocene complexes.
•A reducing reagent for the synthesis of optically active N-protected amino alcohols and peptide alcohols.
•Employed in the efficient reduction of N-Boc amino acid secondary amides leading to chiral diamines.
•You can Use Boc-Anhydride (you can find it on my listings) to protect an amine forming a carbonyl then reducing it with Red-Al which will leave a single methyl group on the amine thus forming a methylamine-compound.
🟢(More information)🟢
Red-Al® Reducing Agent
Red-Al®, or sodium bis(2-methoxyethoxy)aluminum dihydride (Vitride®, SMEAH), is a versatile reducing agent and a good substitute for LiAlH4 in many reactions. Red-Al® is nonpyrophoric, although still moisture-sensitive, and is available in solution, allowing for easier handling compared to LiAlH4.
Red-Al® is particularly effective at the reduction of epoxides. A recent example employs Red-Al® in a key step in the asymmetric synthesis of (R)-fluoxetine hydrochloride. The enantiomerically pure α,β-epoxyamide was reduced by Red-Al® in the presence of 15-crown-5 to produce the β-hydroxyamide in good yield and excellent selectivity (Scheme 23).1
Red-Al®
Scheme 23
Cao and co-workers utilized Red-Al® to convert propargyl chlorides to allenes, which were subsequently used in a tandem Pauson-Khand reaction to create 3,7-diisopropylsilyldicyclopenta-[a,e]pentalene, a 14π annulene (Scheme 24).2
Cao and co-workers utilized Red-Al®
Scheme 24
The preparation of highly functionalized α,β-disubstituted alkenoates can be achieved under mild conditions by reducing an acetylenic ester with Red-Al® and quenching the reaction with iodine to yield the vinyl iodide. The vinyl iodide can be subsequently transformed via Sonogashira or Stille coupling to form the desired α,β-disubstituted alkenoates (Scheme 25).
Preparation of highly functionalized α,β-disubstituted alkenoates
Scheme 25
Red-Al® displays excellent (E)-selectivity in the reduction and does not reduce the methyl ester.3 Red-Al® reduction can selectively produce dialdehydes from aromatic diesters in the presence of N-methylpiperazine (Scheme 26). Although Red-Al® is regularly employed in the reduction of esters to aldehydes, reduction of the diester without the addition of the amine produced only the dicarbinol.4
Red-Al® displays excellent (E)-selectivity in the reduction and does not reduce the methyl ester.3 Red-Al® reduction can selectively produce dialdehydes from aromatic diesters in the presence of N-methylpiperazine (Scheme 26). Although Red-Al® is regularly employed in the reduction of esters to aldehydes, reduction of the diester without the addition of the amine produced only the dicarbinol.4
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Buyer must be 21 years of age. Buyer assumes all liability for the use of this item. Buyer agrees to not hold the seller or Ebay liable for the use of this item. Buyer agrees to use this item in accordance with all local, state, and federal laws. This is for laboratory and scientific use only! Shipping will comply with all USPS regulations. Item is NOT regulated by the DOT.
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